Lots of mods to satisfy your urge for a heavily modded minecraft experiance. All mods should work together. I reccomend you allocate more memory to your minecraft client.

Automate all your needs with the following mods:

Thermal Expansion

Buildcraft

Ender IO

Mekanism

Immersive Engineering

Applied Energistics 2

Minefactory

RFTools

These mods will alow you to create systems which will work away witout your interaction. Create factorys or automate simple but tiresome task. Who really wants to chop down trees when you reach the late game? Create a tree farm or a quarry to accelerate you to some of the more interesting late game items without worrying about the basics.

Magical Powers at your fingers:

Thaumcraft

Mystcraft

~~Blood Magic~~

Create a thaumonomicon and begin your journey. Stick to a safe path or explore the darker side of the mod. "Strange whispers reveal secrets to you." Otherwise you can magically create a book that will literally transport

Science, basically the cool stuff:

Galacticraft

ICBM

Go to space or create a space station. You won't get too lonely as the space mobs will be there to support you. Once your done with that return to the overworld to fire missiles at it and

Misc

MultiMine :Allows a block to retain its damage value for a short amount of time. (It will stay partially mined.)

Villager Noses :

A fun little mod. The name is as weird as the mod.

FTBUtils

FTBLIB

Have fun and remember to allocate more memory to the client.

YSPack 2.0

Better Builder's Wands

BetterFps

BiblioCraft

Biomes O' Plenty

Brandon's Core

Buildcraft

Carpenter's Blocks

CodeChickenCore

CoFH Core

Cooking for Blockheads

CraftTweaker

Darkcore

Decocraft

Draconic Evolution

Ender IO

EnderCore

Extra Utilities

FastCraft

Forestry

Get Off My Tardis