This is a decently kitchensink modpack with a few changes fitted around my play style. The pack can be deadly but, if you can avoid this, progression should be pretty quick. However there are a lot of things to do late game.

Most notable changes

4k, 16k and 64k ae2 cells are cheaper (I hate the recursive recipes).
Ores generate in rarer bigger chunks, some ores might be hard to find, but you should be able to find workarounds for those.
Pitchblend is only found beneath oceans and mushroom biomes (and of course in the end), it is quite abundant there.
There are more caves and open spaces underground. This makes the world more beautiful (in my opinion) and a bit more dangerous. :)
Most early game energy storage is disabled to incentivize the creation of sustainable ways of producing energy.

Points of interest

Farming rainbow trees can be a very good source of a certain metal.
Finding villages wont be a problem and you should be able to obtain some nice starting items there.
I can recommend automating everything (mining, lubricant, ethanol etc...). If you are familiar with rotarycraft this shouldn't be a problem.
It is advised to use Pam's mob drop crops (instead of more traditional monster farms) when playing on servers.
It is also advised to craft a hammer from the hammerz mod as soon as possible, this will make mining the large ore veins a lot easier.

Potential goals

Nuclear reactors
Chromaticraft
Become a mage
Keep bees
Create a nice dimension with mystcraft (The super OP pages are disabled)

Potentially helpful sites

These links are mainly for those who want to explore mods they don't know yet or to see what can be done in the modpack.

Getting started with Blood magic
Getting started with Immersive Engineering
Getting started with Mystcraft
Getting started with RotaryCraft (don't forget to read the in-game handbook for exact numbers on power requirements and load limits)
Getting started with Botania
Getting started with Thaumcraft, reading the Thaumonomicon should also suffice.
Getting started with bees
Twilight Forest Progression
Blood Arsenal additions
If you want to read about Chromaticraft (I highly recommend trying chromaticraft yourself before looking at any guide)
If you prefer watching videos about Chromaticraft
Documentation for programming turtles
Breeding special bees
Reactorcraft end game, for those who think they built it all.

If there are ever glitches, errors, crashes or other problems come to me first, before going to any of the mod authors.

Suggestions are also very welcome. My discord: derosalie

Old but iron

AE2 Stuff

AI Improvements

Another One Bites the Dust

AppleCore

Applied Energistics 2

Aroma1997Core

Aroma1997s Dimensional World

AromaBackup

AtomicStryker's Infernal Mobs

Avaritia

Avaritiaddons

BdLib

BeeBetterAtBees

Better Builder's Wands

BetterAchievements

BetterFps

Blood Arsenal

Blood Magic

Botania

Buildcraft Compat