Runes can be configured in any order you wish. You can also prioritize runes with shorter cooldowns in either order as well, and they will switch dynamically.
People seem to think its the sword graphic only. There are many simple looks that DKiRunes is capable of to maximize UI real estate.
Default layout for DKIRune Tracker and DKIDisease/Pestilence Tracker
Simple Interface
It's not a real disease, but Blood tanks need to be just as aware of this debuff as their diseases!
Spinning animation highlights runes enabled by RE. Watch the demo video to do it justice.