For World of Warcraft (Retail). Not tested in Classic.
This simple addon checks to see whether the Blizzard Addon Profiler is enabled at first login. If it is, it declares a console variable that controls this function. It then sets that variable to 0 (off).
This change will persist through character switches/logouts, but will be reset to the default setting when the client quits.
You can confirm for yourself whether the profiler is disabled with the chat window command /dump C_AddOnProfiler.IsEnabled() -- "false" means it's turned off. That's what you want to see.
That's all this does. Really.
Issues should be submitted to the GitHub project.